Research Area

Macromolecular Platforms for Translational Medicine and Biomanufacturing

Direction of Research:
Macromolecules platform for translational medicine and bio-manufacturing is a manufacturing science which takes cell, reactive molecules and biomaterials as the basic unit, is an emerging discipline birth from the cross of engineering, materials, information, life science, and many other large disciplines.
Focus on:
Cell/organ 3D printing and in vitro biological function structure system building;Bionic design and manufacturing, regenerative medicine mode manufacturing;Tissue engineering blood vessel, myocardium and cornea reconstruction;Biological/pathological/pharmacological model and new medicine detection model manufacturing;Cell based cells/tissues/organs chip manufacturing;Biological machinery equipment and living systems manufacturing;Advanced biological manufacturing equipment’s research and manufacturing;
Core-PIs:
  • Wei Sun

  • Tao Xu

  • Seung-Wuk Lee

  • Shaohua Ma

Cancer Biomarkers, Therapeutics and Theranostics

Direction of Research:
The discovery of new cancer biomarkers and therapeutic targets, the development of in vivo and in vitro detection technologies to identify cancer biomarkers, development of therapeutic approaches and agents against cancer, and the targeted delivery of therapeutics to tumor cells. In parallel, researchers in Lab 3b conduct basic research in the areas of cancer biology.
Focus on:
The identification and validation of new biomarkers and biosensors for early detection of cancer in humans;The development of novel drug targeting and delivery systems to treat human cancer; Improved methods for industrial scale production of protein and small molecule drug-based therapeutics to treat cancer;
Core-PIs:
  • Laiqiang Huang

  • Lan Ma

  • Gerard Marriott

Biomedical Detection and Imaging

Direction of Research:
The goal of this laboratory is to develop and implement novel optical techniques and instruments for biomedical detection or imaging of cells and tissues for in vitro, in vivo and in situ applications. Research activities are directed to 1. Develop polarization scattering based label-free optical techniques for imaging biomedical species at the cellular level.  2. Identify new biomarkers or biophysical features for precision diagnosis. 3. Generate 3-dimensional culture model for studying the different types of tissues.
Focus on:
We will primarily study label-free imaging methods based on polarized photon scattering, including the behavior of polarized photon propagating in turbid media, accurate measurements of polarization states and Mueller matrices, extraction of microstructural feature specific polarization parameters, and apply the new methods in biomedical applications. In the meantime, we will implement established optical techniques such as Raman, optical coherence tomography (OCT), one/two photon laser scanning fluorescence microscopy and nonlinear optics microscopy, and couple different techniques to investigating molecular physiology and pathophysiology of cells and tissues related to human diseases. We will also generate new chemical and genetic sensors for carrying on quantitative characterization of intracellular dynamics and for monitoring protein functions, cell physiology or tissue homeostasis in model systems.
Core-PIs:
  • Gerard Marriott

  • Hui Ma

  • Xiaohua Gong

  • Yaojiong Wu

  • Lu Chen

  • Peiwu Qin

Stem Cell Therapy and Regenerative Medicine

Direction of Research:
Many organs fail due to a shortage of functional cells. Stem cells have the potential to differentiate into specific cell types and thereby repopulate cells in failing organs. With integrated knowledge of the principles and practices of stem cell biology, biomaterial science and bioengineering, Lab 3d develops novel stem cell-based therapies to generate new tissues and organs-the long-term goal of these studies is to apply stem cell techniques to cure diseases that are currently untreatable.
Focus on:
understand the properties and functions of the stem cell microenvironment, and to develop new approaches to promote rejuvenation and differentiation of stem cells that collectively restore function to failing organs;To engineer (stem) cells to maximize trafficking to target organs via their circulation through blood vessels,targeted migration and engraftment, and ultimately therapeutic efficacy in ameliorating diseases;To develop new tissues and organs through appropriate integration of novel technologies in regenerative medicine, biomaterials and engineering to be used for drug-screening, as in vitro models of diseases, and ultimately for stem cell replacement therapies in humans;
Core-PIs:
  • Gerard Marriott

  • Yaojiong Wu

  • Wei Sun

  • Tao Xu

  • Xiaohua Gong

Integrated Molecular Diagnostic System

Direction of Research:
The IMDS lab has developed three research topics (1) smart implantable biochips; (2) Neuromodulation; (3) functional biomaterials research. Currently our main technologies include: Technology1: In vivo diagnosis and detection using implantable biochips Technology 2: Neuromodulation and micro-implamable device Technology 3: Functional biomaterials research (drug delivery, tissue engineering)
Focus on:
Design, testing and translational application of integrated sensors and point of care devices for building smart implantable biochips and diagnostic methods;Develop minimally invasive therapeutic technologies and products for combating epilepsy and stroke;
Core-PIs:
  • Ting Xu

  • Jing Cheng

  • Luming Li

Oncotherapeutics

Direction of Research:
The overarching aim of this laboratory is to characterize the biology of, and develop methods of inhibition of,novel and clinically relevant proteins involved in the pathophysiology of breast and other functionally related cancers. We are focused to develop proof of principle inhibitory strategies to demonstrate the potential utility of these targets in oncology and generate novel therapeutic agents for eventual clinical use.Hence,evaluation of individual molecules for their potential therapeutic application and commercial exploitation also forms an important component of the work.
Focus on:
The identification of novel secreted or membrane bound therapeutic targets in oncology;The role of these identified proteins in cancer cell self-renewal and metastasis;Mechanistic interactions with chemotherapeutics targeted therapeutics used clinically;Development of novel therapeutic agents;Development of companion diagnostics for therapeutic efficacy;
Core-PIs:
  • Peter E. Lobie